与COVID-19疫苗相关的月经干扰:一个全面的系统审查和元分析
Kunchok Dorjee1,2, R C Sadoff1, Farima Rahimi Mansour3
1Center for Tuberculosis and AIDS Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
COVID-19疫苗与月经周期长度轻微增加以及其他月经干扰的小风险有关. 这些效应通常是暂时的,在临床上是微不足道的,在接种后的第二个周期中,周期长度会恢复到正常.
科学领域:
- 免疫学和疫苗学 免疫学和疫苗学
- 生殖健康和内分泌学
背景情况:
- 由于研究方法和结果的不同,COVID-19疫苗对月经周期的影响仍然不清楚.
- 月经周期的变化可能会影响疫苗的接受,需要清晰的疫苗效应数据.
研究的目的:
- 系统地评估COVID-19疫苗接种与月经干扰之间的关联.
- 量化疫苗接种后月经周期长度,出血模式和绝经后出血变化的风险.
主要方法:
- 在Medline,Embase和Web of Science进行了全面的文献搜索.
- 用Shore调整的置信区间进行固定效应元分析,分析了17项涉及超过190万参与者的研究数据.
主要成果:
- 疫苗接种后观察到月经周期较长的风险增加了19%,在第一剂和第二剂接种后,周期长度暂时增加不到一天.
- 月经周期变化的风险在接种疫苗后的第二个周期恢复到基线.
- 对于更重的月经流量,统计学上没有显著的增加,而绝经后出血增加了7%,意外出血增加了16-41%.
结论:
- COVID-19疫苗与月经干扰风险的轻微暂时增加有关.
- 观察到的月经变化通常在临床上是微不足道的,并在两个周期内消失.
- 接种疫苗的接种者应接受关于潜在的,轻微的月经周期变化的咨询.
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