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Microinjection for Transgenesis and Genome Editing in Threespine Sticklebacks
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远距离相关的远鱼之间免疫基因的多重水平转移
Maxime Policarpo1, Walter Salzburger1, Florian Maumus2
1Zoological Institute, Department of Environmental Sciences, University of Basel, Basel, Switzerland.
Molecular biology and evolution
|May 16, 2025
概括
鱼类之间水平基因转移 (HGT) 比以前认为的更为常见. 这项研究确定了19个teleost-to-teleost HGT事件,转移的基因通常与免疫或毛孔形成有关,表明适应性优势.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 分子生物学分子生物学
背景情况:
- 水平基因转移 (HGT) 是一个重要的进化机制,特别是在 prokaryotes.
- 虽然HGT在真核生物中不太常见,但它可以推动主要的适应.
- 细胞HGT研究主要集中在域间转移上,对细胞到细胞事件的调查有限.
研究的目的:
- 为了研究HGT在远鱼 (光鱼) 中的频率和影响.
- 为了确定特定的基因和涉及到远距离到远距离HGT的血统.
- 探索转移基因对接收鱼类物种的功能影响.
主要方法:
- 在242种光鱼物种中进行了大规模的HGT基因组调查.
- 分析了基因系谱,同义分歧和基因组位置,以确定HGT事件.
- 与已知的远距离鱼类进化树相比较的系遗传模式.
主要成果:
- 确定了19个不同的teleost-to-teleost HGT事件,涉及11个teleost顺序中的17个基因.
- 关于HGT的证据包括较低的同名分歧,不相称的基因类型和非合成基因位置.
- 转移的基因经常与免疫或毛孔形成功能有关,在奥斯梅里formes和Clupeiformes类之间有着显著的事件度.
结论:
- 远距离到远距离的HGT发生了多次,是鱼类进化的一个显著因素.
- 免疫和毛孔形成基因可能会被优先转移,因为它们赋予了选择性优势.
- 需要进一步的研究来量化HGT事件及其进化影响,考虑到杂交的潜在贡献.
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Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...

