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用于膀癌治疗的抗生物受体网状微运动器

Jun Sun¹, Ran Chu², Xiaoqian Wu¹

¹State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Journal of the American Chemical Society

|May 16, 2025

概括

在癌症治疗中使用酶驱动的纳米发动机的寿命更长. 新的富含的金属有机框架可以防止失活, 提高膀癌症的治疗效果.

科学领域:

生物医学工程
材料科学
纳米技术

背景情况:

由酶驱动的微/纳米电机 (MNM) 由于在瘤微环境中快速失活,因此在生物医学上应用有限.
生物化,即发动机被生物成分污染, 显著缩短了它们的使用寿命.

研究的目的:

为膀癌治疗设计具有增强运动性的抗生物受体化尿酶驱动的MOF电机 (Ur-MOFtors).
调查持续运动和抗生物化特性背后的机制.

主要方法:

使用富含键的金属有机框架 (MOF) 来制造酶驱动的电机.
在缩尿素溶液中研究的运动寿命.
使用现场红外光谱和密度函数理论来阐明持久运动的机制.
通过离子自我扩散和化学反应对尿素进行自我推进.
通过静脉注射治疗膀癌的疗效.

主要成果:

在缩尿素中,Ur-MOFtors的运动寿命超过了90分钟,比尿素酶吸附的MOF提高了18倍.
实现了优异的抗生物化,保持了与原生尿素酶相比较的酶活性.
确定MOF骨架和催化产品之间的结为持续运动的关键.
证实了离子自我扩散作为对尿素的积极化学反应的推进机制.

结论:

富含键的MOF为创造具有延长寿命的抗生物受酶电机提供了可行的策略.
Ur-MOFtors为先进的治疗机器人提供了一个有前途的平台,特别是通过静脉注射治疗膀癌症.
这种方法克服了生理环境中酶电机的短寿命和失活的局限性.

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