离子环境调节的核和稳定性的多尺度纳米域在无表面活性剂的微乳液中
Yawen Gao1, Changsheng Chen1, Mingbo Li2
1New Cornerstone Science Laboratory, Center for Combustion Energy, Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China.
Journal of colloid and interface science
|May 16, 2025
概括
没有表面活性剂的微乳液显示可调节的纳米域形成. 极端的pH和离子强度控制滴滴大小和稳定性,由奥斯瓦尔德成熟驱动,为材料合成和药物输送提供了洞察力.
科学领域:
- 物理化学 物理化学
- 合体和表面化学
- 材料科学 材料科学 材料科学
背景情况:
- 在三元液体混合物中的纳米聚类可以在没有表面活性剂的情况下发生.
- 没有表面活性剂的微乳液 (SFME) 为纳米领域形成提供了一个可调的平台.
研究的目的:
- 为了阐明多尺度纳米域的核和稳定性在一个跨-anethol,乙醇和水SFME系统.
- 研究水性离子环境,特别是pH值和离子强度对SFME结构的影响.
主要方法:
- 使用了动态光散射 (DLS) 和纳米粒子跟踪分析 (NTA).
- 检查各种组成的直接 (O/W) 和反向 (W/O) SFME 结构.
主要成果:
- 极端的pH值 (<3或>10) 和离子强度显著影响纳米域核和生长.
- 在极端条件下,油入水 (O/W) SFME 呈现出更大的水滴大小和更低的数量密度.
- 油中的水 (W/O) SFME 显示稳定的反向聚合物结构.
- 奥斯瓦尔德成熟被确定为滴滴生长的主要机制,受pH的影响.
- 在中性的pH值下,静电排斥可以防止滴滴凝聚.
结论:
- SFME纳米域的形成和稳定性对pH值和离子强度非常敏感.
- 奥斯瓦尔德成熟是SFME滴滴生长的一个关键过程,由离子条件调节.
- 了解这些行为为材料合成,药物溶解和凝制备中的应用提供了洞察力.
相关概念视频
Mechanisms of Membrane Domain Formation
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
The Colloidal State
The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Surface Active Agents
Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
Micelles
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...


