探索祖母暴露于空气污染和孙子ASD风险之间的联系:加利福尼亚州的一项基于多代人口的研究
Karl O'Sharkey1, Ting Chow1, Sanjali Mitra1
1Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
Environment international
|May 16, 2025
概括
怀孕期间祖母暴露于空气污染可能会增加孙子患自闭症的风险. 这种多代效应,特别是来自PM2.5,表明母亲暴露的复合风险.
科学领域:
- 环境健康 环境健康
- 神经发育障碍 神经发育障碍
- 流行病学 流行病学
背景情况:
- 自闭症谱系障碍 (ASD) 的患病率正在上升,遗传是关键因素.
- 像空气污染 (AP) 这样的环境因素与ASD风险有关.
- 暴露于AP的多代影响,特别是在祖母怀孕期间,仍然未经检查.
研究的目的:
- 调查祖母妊娠期AP暴露与孙子中ASD风险之间的关联.
- 探索AP对ASD的多代影响,考虑母亲和婴儿的暴露.
主要方法:
- 利用来自加利福尼亚州 (1990-2019) 的基于人口的多代队列.
- 检查了祖母暴露于AP (PM2.5,NO2,O3) 和孙子ASD风险之间的关联.
- 使用后勤回归,调整母婴AP暴露,使用先进的土地利用回归和机器学习模型.
主要成果:
- 在怀孕期间,祖母暴露于PM2.5和NO2与孙子增加ASD风险有关.
- 在调整为母亲暴露后,在祖母怀孕期间的PM2.5暴露显示出与ASD风险的持续关联.
- 在祖母和母亲怀孕中,对PM2.5和NO2的联合高暴露表明对孙子ASD风险的影响最大.
结论:
- 孕期暴露于祖母的空气污染可能会影响孙子的自闭症风险.
- 多代AP暴露似乎增加了自闭症综合风险,突出了跨世代早期环境影响的重要性.
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