胃食道逆流性疾病与患有Mycobacterium avium复杂肺部感染的患者的疾病严重程度无关
Mayank N Nihalani1, Manar Al Jawish1, Wendelyn Bosch2
1Division of Gastroenterology, Department of Medicine, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA.
Respiratory investigation
|May 16, 2025
概括
胃食道逆流性疾病 (GERD) 影响26.5%的患有Mycobacterium avium复合体 (MAC) 肺部感染的患者. 这项研究没有发现GERD与MAC肺部感染患者的更糟糕结果之间的关联.
科学领域:
- 肺部病理学 肺部病理学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 菌复合体 (MAC) 肺部感染与胃食道逆流症 (GERD) 有关.
- GERD对MAC肺部感染的临床结果的影响尚不清楚.
- 这项研究旨在确定GERD患病率及其与MAC患者结果的关联.
研究的目的:
- 在被诊断为MAC肺部感染的患者中评估GERD的患病率.
- 研究这些患者GERD和临床结果之间的关联,包括肺功能和治疗反应.
主要方法:
- 对已确认MAC肺部感染的成年患者进行了回顾性分析,这些患者接受了门诊pH监测.
- 病理性酸性逆流被定义为总距离酸暴露时间≥6%.
- 评估肺功能测试 (PFT) 和MAC治疗参数.
主要成果:
- 在132名患者中,有26.5%的患者表现出病理性酸性反流 (酸性暴露时间≥6%).
- 在患有和没有GERD的患者之间,没有观察到PFT (FEV1,FVC,DLCO) 的显著差异.
- 根据GERD状态,在MAC治疗结果中没有发现差异,包括抗菌药物治疗或需要带切除术.
结论:
- 在患有MAC肺部感染的患者中,GERD的患病率为26.5%,由门诊pH监测确定.
- 在患有MAC肺部感染的患者中,GERD与较差的肺功能或治疗结果无关.
- 进一步的研究是有必要的,以充分理解GERD和MAC肺部感染之间的关系.
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