相关实验视频
Updated: May 8, 2026

07:49
Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
由于黄虫刺的局部和广泛反应:它与系统反应的关系
Alberto Palacios Cañas1, Miriam Clar Castelló1, Stephanie Bracamonte Odreman1
1Sección de Alergología del Hospital General Universitario de Ciudad Real, Spain.
概括
患有广泛局部过敏反应 (ELAR) 的患者对Hymenoptera刺痛 (Hs) 发生系统性反应 (SR-HV) 的风险较低. 对黄斑虫毒液 (HV) 的敏感性不会显著增加这种风险.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 黄虫刺伤 (Hs) 可以引发过敏反应,从局部到严重的系统反应,对黄虫毒液 (HV).
- 在经历了对HV的广泛局部过敏反应 (ELAR) 后,发展Hymenoptera毒液系统反应 (HV-SR) 的风险受到争论.
研究的目的:
- 评估具有至少一个先前ELAR史的个体的HV-SR风险.
- 确定HV敏感度在预测未来HV-SR中的重要性.
- 调查对常见的吸入剂和食物敏感性的流行情况.
主要方法:
- 一个综合的回顾性 (2000-2015年) 和前性 (2016-2023年) 研究设计.
- 包括已记录的对黑虫刺伤的ELAR患者.
- 定期监测HV-SR,HV敏感性 (特定IgE) 和其他过敏敏感性 (皮肤刺伤测试).
主要成果:
- 在281名患有ELAR的患者中,只有2人在回顾阶段发展出HV-SR;3人在前阶段.
- 在224名患者中,有146名患者 (65%) 的HV特异性IgE测试显示了敏感性.
- 皮肤刺痛测试发现54名患者对花粉敏感,8名患者对食物敏感.
结论:
- 在ELAR后发展HV-SR的可能性很低,无论HV敏感性状态如何.
- 亚托皮性倾向 (对吸入剂/食物的敏感性) 似乎不会影响未来HV-SR的风险.
相关概念视频
Allergic Reactions
Overview
Allergic Drug Reactions
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

