灵活的自然深度环氧溶剂提取与前列切换HPLC-FLD相结合,用于分析迁移研究的多种样本矩阵中的光漂白剂
Yuchuan Zheng1, Zikai Zheng1, Xianfeng Huang1
1Hygiene Detection Center, School of Public Health, Southern Medical University (NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou 510515, Guangdong, China.
Journal of chromatography. A
|May 16, 2025
概括
一种使用天然深层水溶剂 (NADES) 和HPLC-FLD的新型绿色分析方法可以有效地检测各种样品中的光漂白剂 (FWA). 这种方法首次揭示了FWA从卫生用品中迁移到血液和尿液中的情况.
科学领域:
- 分析化学 分析化学
- 绿色化学 绿色化学
- 环境科学 环境科学
背景情况:
- 光漂白剂 (FWA) 被广泛使用,但它们的迁移和健康影响需要强大的分析方法.
- 传统的提取方法往往涉及危险的有机溶剂和复杂的程序.
- 需要敏感,准确和环保的技术来分析各种矩阵中的FWA.
研究的目的:
- 开发和验证一种新的,绿色的分析方法来检测FWA.
- 调查FWA从包装和卫生用品迁移到化品,模拟剂,血液和尿液中的情况.
- 用预测建模来评估长期的移民风险.
主要方法:
- 结合天然深度环氧溶剂 (NADES) 提取与前列切换高性能流体色谱与光检测 (HPLC-FLD) 系统.
- 开发了三种NADES提取模式:相反液体-液体提取,液体-固体提取和分散式液体-液体微提取.
- 应用韦布尔模型来描述和预测FWA的迁移行为.
主要成果:
- 纳德斯-HPLC-FLD方法表现出高灵敏度 (LOD低至0.002μg/L) 和准确性 (恢复率为88.2%-114.4%).
- 首次报告FWA从卫生用品迁移到血液和尿液.
- 在血液,尿液,包装材料,化品和化品模拟剂中成功分析了FWA.
结论:
- 开发的基于NADES的分析方法为FWA的确定提供了一种绿色,高效和可靠的替代方案.
- 这项研究提供了FWA迁移的关键数据,突出了化品包装和卫生用品的潜在安全问题.
- 韦布尔模型为评估与FWA相关的长期移民风险提供了一个有价值的工具.
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