关于PXR和CAR的肠道功能
Ye Feng1, Jong-Won Kim2, Wen Xie3
1Department of Endocrinology and Metabolic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Pharmacological research
|May 16, 2025
概括
孕妇X受体 (PXR) 和构成性安德罗斯坦受体 (CAR) 在肠道中发挥关键作用. 这篇评论探讨了它们在结肠癌,肠道屏障完整性和宿主微生物群相互作用中的功能,揭示了复杂的治疗潜力.
科学领域:
- 胃肠病学和肝病学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 孕妇X受体 (PXR) 和构成性安德罗斯坦受体 (CAR) 是对新陈代谢和解毒至关重要的外来生物核受体.
- 虽然肝脏的作用是已知的,但PXR和CAR的肠道功能不太了解.
- 这些受体在肝脏和肠道中高度表达,调节异生菌和内生化学均质.
研究的目的:
- 审查PXR和CAR的肠道功能.
- 为了突出它们在结肠癌,宿主微生物群相互作用,炎症和肠道屏障完整性的参与.
- 强调它们在胃肠道疾病中的复杂,上下文依赖的作用和治疗潜力.
主要方法:
- 文献综述侧重于胃肠道中的PXR和CAR功能.
- 对研究PXR和CAR在结肠癌,肠道微生物群,炎症和屏障功能中的作用的分析.
- 对与微生物代谢物和信号通路 (例如,FGF19,NF-κB) 的受体相互作用的研究结果的综合.
主要成果:
- 在结肠癌中,PXR具有双重作用,作为瘤抑制剂或促进剂.
- CAR调节肠道屏障完整性和免疫反应,特别是在炎症性肠病 (IBD) 中.
- 这两种受体都与肠道微生物群相互作用,影响微生物组成和代谢物产生 (例如,IPA).
- 激活PXR可以通过对抗NF-κB信号来减轻肠道炎症.
- CAR激活会影响胆汁酸代谢和T细胞平衡.
结论:
- 在肠道中,PXR和CAR表现出复杂且取决于环境的功能.
- 这些受体调节关键过程,包括癌症发育,免疫反应和屏障功能.
- 了解这些作用为各种胃肠道疾病提供了潜在的治疗点.
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