胰岛素类生长因子-1 反映了肝脏疾病的阶段,并改善了与肝脏相关的死亡率的预测
Carolin V Schneider1, Stefan Gross2, Sriram Balasubramani1
1Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Health Care Provider of the European Reference Network on Rare Liver Disorders (ERN RARE LIVER), Aachen, Germany.
概括
现在可以使用一种新的查工具来识别与肝脏相关死亡 (LRD) 的风险. 胺转移酶 (GGT) -胰岛素样生长因子-1 (IGF-1) 评分准确预测LRD,优于现有方法.
科学领域:
- 肝病学和临床生物化学.
- 发现和验证用于预测肝病的生物标志物.
背景情况:
- 与肝脏相关的死亡率 (LRD) 是一个日益严重的公共卫生问题,特别影响年轻人群.
- 目前缺乏用于早期LRD风险检测的工具.
研究的目的:
- 使用英国生物银行 (UKB) 数据识别LRD的预测因素.
- 为了验证血清胰岛素样生长因子-1 (IGF-1) 作为LRD预测因子.
- 开发和验证一个新的LRD风险评分.
主要方法:
- 分析英国生物库数据 (325,981名参与者,平均随访13.5年,846名LRD) 以确定预测因子.
- 在不同肝病病因和纤维化阶段的独立队列中验证IGF-1.
- 使用考克斯比例危险模型和在单独的UKB队列 (83,528名参与者,237名LRD) 中验证,开发了玛-氨基转移酶 (GGT) -IGF-1评分.
主要成果:
- 在UKB培训队列中,GGT和IGF-1被确定为关键的LRD预测因子 (AUROC>80%).
- 而IGF-1的肝脏特异性比GGT的肝脏特异性高.
- 新的GGT-IGF-1得分实现了LRD预测的AUROC值为0.87,显著超过已建立的风险得分 (AUROC值为0.77-0.81).
结论:
- 血清IGF-1是LRD的有价值和可靠的预测剂.
- GGT-IGF-1评分是一个新的,基于人口的LRD查工具.
- 这个新工具超过了当前风险评估得分的表现.
相关概念视频
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:30Liver Physiology
456
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
456