在北京, 2015-2023年常见的人类冠状病毒的流行病学和遗传多样性:一个潜在的多中心研究研究
Qi Huang1, Lu Kang2, Xiaofeng Wei2
1School of Public Health, Capital Medical University, Beijing, China; Beijing Center for Disease Prevention and Control, Beijing Academy for Preventive Medicine, Beijing Institute of Tuberculosis Control Research and Prevention, Beijing, China.
概括
在北京的COVID-19期间,常见的人类冠状病毒 (HCoV) 检测率增加. 这项研究详细介绍了它们独特的流行病学,遗传突变和易受感染的种群,强调了持续监测的必要性.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 常见的人类冠状病毒 (HCoV) 是重要的呼吸道病原体.
- 了解它们的流行病学和遗传进化是至关重要的,尤其是在COVID-19大流行病等全球卫生危机期间.
研究的目的:
- 调查北京四种常见HCoV的流行病学和遗传特征.
- 分析与COVID-19大流行有关的HCoV趋势.
主要方法:
- 从2015年到2023年在35家医院收集了急性呼吸道感染 (ARTIs) 患者的临床样本.
- 使用实时PCR检测到的HCoV,其次是S基因测序和家族遗传分析.
主要成果:
- 人类冠状病毒检测率为1.55% (909/58,550),在COVID-19大流行期间显著增加 (P < 0.001).
- 峰值季节是7月至10月,HCoV-NL63和HCoV-229E呈现年度交替. 老年人 (≥60岁) 和幼儿 (0-5岁) 受影响最多. HCoV-229E与严重的社区获得性肺炎 (sCAP) 有关.
- 遗传学分析表明选择压力为负,并确定了常见的氨基酸突变. HCoV-229E在2021年后形成了一个新的血统.
结论:
- 四种常见的HCoV表现出不同的流行病学模式,特定的易感年龄组和流行突变,特别是在COVID-19时代.
- 持续的流行病学监测和遗传表征对于早期检测和预测新出现的冠状病毒至关重要.
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