相关实验视频

Updated: May 20, 2025

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

使用非破坏性和快速的紫外线成像方法确定含有药物的无形固体分散剂的药物含量

Anna Péter-Haraszti¹, Liliána Györgyi Bakucz¹, Lilla Alexandra Mészáros¹

¹Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary.

International journal of pharmaceutics

|May 16, 2025

概括

紫外线成像提供了一种快速,具有成本效益的方法来量化无形固体分散 (ASD) 片中的药物含量. 这个过程分析技术 (PAT) 工具准确地测量了活性药物成分 (API) 的水平,有助于制药质量控制.

科学领域:

制药技术制药技术制药技术
分析化学分析化学
过程分析技术过程分析技术

背景情况:

无形固体分散 (ASD) 对于提高药物的溶解性和生物可用性至关重要.
需要有效的质量控制方法用于ASD制药,特别是那些通过连续工艺制造的药物.

研究的目的:

评估紫外线成像作为一种快速,非破坏性的过程分析技术 (PAT) 工具,用于量化ASD片中的药物含量.
评估紫外线成像的能力,以区分分批量和连续制造过程的ASD平板电脑.

主要方法:

ASD纤维是由电制成的,并使用批量和连续方法与辅助剂混合.
药片被压缩,并使用紫外线成像来捕捉药物的光.
部分最小平方回归模型是使用图像数据开发的,用于活性药物成分 (API) 的量化.

主要成果:

紫外线成像成功量化了ASD片中的API含量,准确度很高 (RMSEP 0.381 w/w%,4.59%的相对误差).
紫外线图像的主要组件分析区分了批量和连续混合过程中的片.
开发的模型通过外部验证证明了可靠性.

结论:

紫外线成像是一种可行的,具有成本效益的PAT工具,用于实时监测和质量控制ASD药片制造中的药品制造.
该方法支持批量制造和连续制造模式,为流程理解和控制提供了显著的优势.
紫外线成像检测工艺变化的能力突出了其在确保产品的一致性和防止假冒药物的潜力.

关键词:

无形固体的分散性固体.毒品含量毒品含量毒品含量机器视觉机器视觉机器视觉过程分析技术过程分析技术药片药片药片药片紫外线成像技术紫外线成像技术

更多相关视频

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

相关概念视频

$X-ray Diffraction of Biological Samples$ 01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are scattered by the electron clouds around the sample atoms. The X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

Ultraviolet–visible (UV–visible or UV–Vis) spectroscopy is an analytical technique that investigates the interaction between matter and UV–Vis light within the electromagnetic spectrum. This method is widely used for its versatility, simplicity, and relatively quick data acquisition, making it valuable for both qualitative and quantitative analysis. When UV–Vis radiation passes through a material, molecules absorb light depending on the energy required for...

UV–Vis Spectrometers

UV–Vis Spectrometers

The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell.