开发3D打印的Captopril迷你片,具有针对儿童高血压治疗的定制释放配置文件
Mariangela Totaro1, Giuseppe Francesco Racaniello1, Antonio Lopalco1
1Department of Pharmacy - Pharmaceutical Sciences, University of Bari Aldo Moro, Orabona St. 4, 70125 Bari, Italy.
International journal of pharmaceutics
|May 16, 2025
概括
直接粉末挤出3D打印开发了Captopril迷你药片用于儿科高血压. 这项技术允许精确的剂量和可定制的释放配置文件,解决当前儿科Captopril配方的局限性.
科学领域:
- 制药技术 制药技术 制药技术
- 在医学中使用3D打印.
- 儿科药理学 儿科药理学
背景情况:
- 儿科动脉高血压影响5-10%的儿童,需要像卡普托普里尔 (CPT) 这样的治疗.
- 目前的CPT配方在儿科中存在剂量挑战,原因是有限的小剂量强度,往往导致非标签使用.
- 需要为儿科患者提供精确,可定制的CPT剂型.
研究的目的:
- 开发立即释放的卡普托普里尔 (CPT) 迷你药片 (MTs) 用于儿科.
- 探索直接粉末挤出 (DPE) 3D打印的应用,以创建可定制的儿科药物配方.
- 通过3D打印实现精确控制CPT剂量和释放配置文件.
主要方法:
- 使用CPT装载的MTs是使用DPE3D打印机 (3DForMe®) 制造的.
- 聚乙醇 (PVA) 和基甲基纤维素 (HPMC) 用作载体和共聚合物.
- 在模拟的胃状况 (禁食和食后) 中,MTs的特征是统一性和药物释放.
主要成果:
- 3D打印的MT显示出一致的尺寸和不同的填充百分比.
- 50%和75%充满的MT显示在快速溶解的媒体中迅速溶解和立即释放药物.
- 其他配方在两个模拟的胃环境中都表现出长时间的药物释放.
结论:
- DPE 3D 打印提供了一种可行的方法,用于生产精确和可定制的 CPT 迷你平板电脑用于儿科.
- 这项技术可以解决儿童高血压管理中个性化医学的关键需求.
- 通过3D打印,可以从单一的聚合物系统灵活地制造即时和持续释放型材.
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