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同轴电喷涂的,加载库尔库的半孔和聚合物复合物涂层微针的开发和特征
Amna Ali1, Saman Zafar2, Tahir Ali Chohan3
1Leicester School of Pharmacy, De Montfort University, Leicester, United Kingdom.
International journal of pharmaceutics
|May 16, 2025
概括
这项研究开发了新型的黄含量高的半孔二氧化纳米球,使用电子喷射进行透皮传递. 微针贴片能够持续释放黄素,增强神经保护治疗潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 黄素的神经保护潜力受到其溶解性差和晶体性质的限制.
- 为难溶性化合物开发有效的透皮药物递送系统 (TDDS) 仍然是一个挑战.
- 半孔纳米圈 (MSNs) 为封装和稳定活性制药成分提供了一个有前途的矩阵.
研究的目的:
- 通过电动力原子化 (EHDA) 和电喷射 (ES) 来合成含有黄素的MSN.
- 通过微针 (MN) 贴片设计这些纳米粒子以持续通过皮肤传递.
- 评估黄素含量较高的MSN对神经保护的封装效率,稳定性和释放动力学.
主要方法:
- 使用同轴电喷涂制造含有黄素的MSN.
- 在MSN中使用XRD和DSC对黄素的无形转化进行表征.
- 在体内进行对接分析,以预测药物聚合物相互作用.
- 纳米颗粒的配方 (<150 nm,>89%的封装效率) 和沉积在固体MN设备上.
- 使用弗朗茨细胞的ex vivo透研究和体内病理学检查.
主要成果:
- 在MSN中成功合成了无形黄素,克服了溶解性差.
- 实现了高封装效率 (>89%) 和纳米粒子大小 (<150 nm).
- 从MN贴片上的MSN中持续释放黄素 (70.41%在120分钟内) 与未封装黄素 (74.72%在40分钟内) 的快速释放相比.
- 在生物体中通过角层成功透了MN.
结论:
- EHDA和ES提供了一种可行的方法,用于创建稳定,无形的黄素载的MSNs.
- 装有黄素-MSN的微针贴片有助于有效的通过皮肤递送药物,并持续释放.
- 这种方法为神经保护剂和其他治疗方法的先进TDDS奠定了基础.
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