马克罗福米纳 phaseolina 角膜炎:治疗方法对局部纳塔米反应不佳的治疗方法
Poornima Tandra1, Sanchita Mitra2, Bhagyashree Madduri3
1Shantilal Shanghvi Cornea Institute, LV Prasad Eye Institute GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India.
BMJ case reports
|May 16, 2025
概括
本案例研究详细介绍了一位患者的状角膜炎感染,由Macrophomina phaseolina引起.
科学领域:
- 眼科医生 眼科 眼科
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
背景情况:
- 真菌角膜炎是视力障碍的重要原因,特别是在热带和亚热带地区.
- 一种土壤菌Macrophomina phaseolina可以引起机会性感染,包括罕见的角质炎.
- 区分马克罗福尔米娜角质炎与其他微生物角质炎,如诺卡迪亚和皮蒂亚,对于有效的治疗至关重要.
研究的目的:
- 在眼部创伤后报告一个Macrophomina phaseolina角膜炎病例.
- 描述这种罕见的真菌感染的临床表现和诊断挑战.
- 为了评估局部伏利可纳和局内安波特的治疗反应,B.
主要方法:
- 一名中年妇女有左眼创伤史,出现了角膜炎的症状.
- 角膜除和涂抹分析揭示了真菌菌,导致识别了Macrophomina phaseolina.
- 患者接受了局部纳塔米辛和口服凯托可纳治疗,后来补充了局部沃里科纳和内侧安福特里辛B注射.
主要成果:
- 纳塔米辛和可纳的初始治疗是无效的,透物以环状的模式进展.
- 添加局部沃里康纳和内流体安波特里辛B导致了积极的临床反应.
- 角膜透物在五个月内完全消失,使用voriconazole单一治疗,没有出现复发.
结论:
- 麦克罗菲米纳角膜炎可以呈现出模仿其他微生物感染的临床特征,从而构成诊断挑战.
- 局部可纳,结合腹腔内安波特里辛B,可以是一个有效的治疗策略,严重的马克罗福米纳角膜炎.
- 这一案例强调了及时的真菌学诊断和定制的抗真菌治疗在治疗复杂角膜炎病例中的重要性.
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