与新生儿维生素D状况和神经发育障碍风险相关的趋同证据:一项丹麦案例-队列研究
Henriette Thisted Horsdal1, Clara Albiñana2, Zhihong Zhu3
1National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark; Centre for Integrated Register-based Research at Aarhus University, Aarhus University, Aarhus, Denmark; Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark.
The lancet. Psychiatry
|May 16, 2025
概括
新生儿维生素D缺乏与精神分裂症,多动症和ASD的风险增加有关. 优化新生儿维生素D水平可能有助于减少这些神经发育障碍的发生率.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学是一种遗传学.
- 公共卫生 公共卫生
背景情况:
- 越来越多的证据将新生儿维生素D缺乏与精神分裂症,多动症和自闭症谱系障碍 (ASD) 的更高风险联系在一起.
- 维生素D的生物标志物,包括25氧维生素D (25OH) D和维生素D结合蛋白 (DBP),以及它们的遗传因素正在研究它们在心理健康中的作用.
- 这项研究建立在现有研究的基础上,通过检查一系列综合性精神障碍,并利用大量基于人口的样本.
研究的目的:
- 调查新生儿维生素D生物标志物 (25(OH) D和DBP) 及其遗传相关物与六种精神疾病风险之间的关联.
- 探索维生素D状态与重大抑郁症,双相情感障碍,精神分裂症,多动症,自闭症和神经性厌食症发展之间的潜在因果关系.
- 提供支持该假设的证据,即优化新生儿维生素D状态可以减轻神经发育障碍的风险.
主要方法:
- 一项基于人口的病例和队列研究,使用了丹麦的健康登记册,从1981年到2012年,包括超过88,000个人.
- 从干燥的血斑中测量新生儿25(OH) D和DBP度.
- 主要分析使用危险比率,而次要分析包括遗传预测因素,多基因风险得分和门德尔随机化来评估关联和因果关系.
主要成果:
- 观察到25~OH) D水平与精神分裂症,自闭症和多动症的风险之间存在显著的反向关系.
- 较低的DBP度也与精神分裂症的风险相反相关.
- 基因分析,包括门德尔随机化,支持较低的维生素D水平与ADHD,ASD和精神分裂症风险增加之间的因果关系.
结论:
- 新生儿维生素D状况与患各种精神障碍的风险有显著联系.
- 这些发现支持这样一个假设:在新生儿中保持足够的维生素D水平可能是减少神经发育障碍的策略.
- 需要进一步的研究和潜在的公共卫生干预措施,重点关注新生儿维生素D补充剂.
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