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Updated: Jun 28, 2026

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
10:53

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

Published on: July 3, 2013

人类ATR-ATRIP的分子结构和抑制机制

Guangxian Wang1, Po Wang1, Zexuan Zheng1

  • 1Department of Radiation Oncology, the First Affiliated Hospital of USTC, MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230000, China.

Science bulletin
|May 16, 2025
PubMed
概括

冷EM结构揭示了形突变和Rad3相关 (ATR) 激酶抑制剂VE-822和RP-3500如何与ATR-ATRIP复合体结合. 这些发现为ATR抑制剂选择性提供了洞察力,并指导了未来的癌症药物设计.

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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b10:20

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