在没有痴呆症的老年人中,睡眠质量,血神经纤维光和认知之间的联系
Hai-Hua Guo1, Dong-Xin Liang2, Qun Zhang1,3,4
1Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Translational psychiatry
|May 16, 2025
概括
睡眠质量差与较高的神经纤维光链 (NFL) 水平和认知衰退有关,这可能表明神经轴损伤. 血NFL部分调解了这种关系,突出了睡眠.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 睡眠质量,神经纤维光链 (NFL) 水平和认知功能之间的相互作用尚未完全理解.
- 高血NFL与神经轴损伤和认知障碍有关.
研究的目的:
- 在没有痴呆症的队列中调查睡眠质量,血NFL水平和认知功能之间的关联.
- 检查血NFL在睡眠质量和认知衰退之间的关系中的调解作用.
主要方法:
- 来自阿尔茨海默病神经成像计划 (ADNI) 队列的640名参与者的分析,提供完整的睡眠和认知数据.
- 使用神经精神病 inventory 睡眠分量级评估睡眠质量.
- 多变量回归和线性混合效应模型用于分析睡眠质量,血NFL和认知措施 (MMSE,MoCA,ADAS13,CDRSB,EF,LAN,MEM) 之间的关联;进行中介分析.
主要成果:
- 较差的睡眠质量与较高的血NFL水平相关 (P <0.05).
- 睡眠质量差与基础认知 (ADAS13,CDRSB,EF,LAN,MEM;Q <0.05) 和加速纵向认知衰退 (MoCA;Q <0.05) 相关.
- 血NFL部分调解了睡眠质量与认知障碍之间的关联 (9.2%26.7%调解).
结论:
- 较差的睡眠质量与认知障碍和加速认知衰退显著相关.
- 血NFL表示的神经轴损伤,可能部分解释睡眠不足和认知缺陷之间的联系.
- 研究结果表明,睡眠质量是维持认知健康的关键因素,可能与阿尔茨海默病的发病相关.
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