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Updated: May 20, 2025

Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog
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Published on: November 5, 2014

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通过向一个Ca2+依赖的全结合位来抑制丁氨酸减弱酶 (PAD1-4)

Leslie A Dakin1, Li Xing1, Justin Hall2

  • 1Medicine Design, Pfizer Inc, Cambridge, MA, USA.

Nature communications
|May 16, 2025
PubMed
概括

研究人员确定了Peptidylarginine deiminases (PAD1-4) 上的一个常见的全位,以开发非共价抑制剂. 这一发现为向PAD酶提供了一种新的策略,这些酶与类风湿性关节炎等疾病有关.

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