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Updated: May 21, 2025

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
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USP37 防止通过 MCM 复杂的 deubiquitination 进行非预定的复杂体卸载

Derek L Bolhuis1,2, Dalia Fleifel1, Thomas Bonacci2

  • 1Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.

Nature communications
|May 16, 2025
PubMed
概括

人类USP37通过使MCM7脱,保持活跃的DNA复制,防止过早的复制体分解. 这种二基因酶保证了基因组的稳定性,并保护细胞免受复制压力.

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