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Updated: Jun 16, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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Published on: December 11, 2017

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在乳腺癌中,APOBEC3突变驱动治疗耐药性

Avantika Gupta1, Andrea Gazzo2, Pier Selenica2

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature genetics
|May 16, 2025
PubMed
概括

阿波蛋白B mRNA编辑酶催化多类3 (APOBEC3) 酶活性驱动的遗传变化导致对乳腺癌疗法的耐药性. 这一发现凸显了APOBEC3作为克服治疗耐药性的潜在生物标志物和治疗标.

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