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Updated: Jun 19, 2026

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
10:39

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening

Published on: April 15, 2017

在心脏微组织中发现了药物诱导的结构性心脏毒性的预测代谢特征

Tara J Bowen1,2, Andrew R Hall3, Gavin R Lloyd4

  • 1School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2 TT, UK.

Archives of toxicology
|May 16, 2025
PubMed
概括

这项研究确定了心脏微组织中的代谢特征,可以预测药物诱导的心脏毒性. 这些发现有助于在药物发现过程中早期发现心脏安全问题.

关键词:
3D三度培养心脏模型在ADME/TK中使用.混合代谢组学 混合代谢组学在MTox700+上使用.代谢生物标志物 代谢生物标志物结构性心脏毒性 结构性心脏毒性

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