间相和间脉冲延迟对组织阻抗和脉冲场除的影响
Edward J Jacobs1, Pedro P Santos1,2, Rafael V Davalos3
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech - Emory University, U.A. Whitaker Building, 313 Ferst Drive, Suite 2101, Atlanta, GA, USA.
Annals of biomedical engineering
|May 16, 2025
概括
高频不可逆电穿孔 (H-FIRE) 中脉冲之间的延迟不会显著影响组织剥离区域或导电性. 这一发现简化了脉冲场除 (PFA) 疗法的参数优化.
科学领域:
- 生物医学工程 生物医学工程
- 电子生理学 电子生理学
- 组织剥离技术 组织剥离技术
背景情况:
- 高频不可逆转电穿孔 (H-FIRE) 使用电脉冲进行非热性组织切除.
- 在H-FIRE中间脉冲延迟 (d1,d2) 可能会影响神经刺激和电化学效应.
- 这些延迟对废弃结果的影响尚未完全理解.
研究的目的:
- 研究介相 (d1) 和介脉 (d2) 延迟在H-FIRE过程中对组织抵抗和切除生成的影响.
- 为了确定延迟是否会影响结核和心脏组织中的电穿孔结果.
- 为改进H-FIRE参数化和计算模型提供数据.
主要方法:
- 通过使用针和板电极,向结核和心脏组织输送电压坡道.
- 在H-FIRE处理过程中记录应用的电压和电流.
- 通过对代谢活动的染色组织来评估不可逆的电穿孔区域.
主要成果:
- 延迟并没有显著改变测试组织中的剥离区域.
- 在亚剥离场中观察到电流,电阻和导电力的显著差异,但在电穿孔后没有.
- 在电解后的不同延迟和脉冲宽度之间没有发现局部导电性的显著差异.
结论:
- 在H-FIRE中间脉冲延迟不会显著影响组织导电性变化或切除区域.
- 研究结果表明,延迟不应影响电场值或焦尔加热.
- 该研究为优化H-FIRE参数和PFA治疗的计算模型提供了洞察力.
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