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与印度2型糖尿病患者和慢性病相关的风险因素:CITE研究,一个横截面,现实世界的观察性研究
Ajay Kumar1, Anirban Mazumdar2, A K Bhattacharjee3
1Private Clinic, Patna, India.
BMC nephrology
|May 16, 2025
概括
慢性病 (CKD) 影响32%的印度2型糖尿病 (T2DM) 患者. 关键的危险因素包括年龄较大,糖尿病持续时间较长,HbA1c较高,血压升高,吸烟以及非素食饮食.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 全球范围内,2型糖尿病 (T2DM) 是慢性病 (CKD) 的主要驱动因素.
- 关于印度T2DM人口中CKD患病率和风险因素的数据有限.
- 印度T2DM评估 (CITE) 研究中的CKD解决了这一数据缺口.
研究的目的:
- 确定印度T2DM患者中CKD的患病率.
- 在这个人群中确定与CKD相关的临床和实验室因素.
- 为可修改的风险因素提供有针对性的干预信息.
主要方法:
- 这是一项多中心,横截面的研究,涉及28个印度中心的3325名T2DM患者.
- 基于持续降低估计的淋巴细胞过率 (eGFR < 60 mL/min/1.73 m2) 或尿中白蛋白与肌素比率 (UACR) 的增加的CKD诊断.
- 使用后勤回归分析来确定CKD的重大风险因素.
主要成果:
- 在研究队列中,CKD的患病率为32%.
- 降低的eGFR与年龄较大,T2DM持续时间较长,HbA1c较高和静脉压升高 (SBP) 有显著的关联.
- 宏蛋白尿 (UACR > 300 mg/g) 与非素食饮食和烟草使用有关. 慢性病的存在增加了并发病率.
结论:
- 在印度T2DM患者中,CKD的流行率很高 (32%).
- 确定的危险因素包括年龄≥60岁,T2DM持续时间,SBP,HbA1c,吸烟,非素食饮食和并发症.
- 建议进行进一步的纵向研究,以确认关联并确定因果关系.
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