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氧化应激生物标志物作为三发症21的新查工具:一个病例控制研究

Sinem Tekin¹, Aydin Ocal², Filiz Yarsilikal Guleroglu²

¹Department of Obstetrics and Gynecology, Haseki Training and Research Hospital Affiliated with the University of Health Sciences, Istanbul, Turkey. drsinemtekin@gmail.com.

BMC pregnancy and childbirth

|May 16, 2025

概括

这项研究发现,在患有唐氏综合征 (DS) 的怀孕中,NAD(P) H脱酶[氨酸] 1 (NQO1) 水平较高,核因素红色素2相关因子2 (NRF2) 水平较低. 这些发现表明,DS的产前查有潜在的生物标志物.

科学领域:

生物化学生物化学
遗传学是一个遗传学.
产前诊断在产前诊断

背景情况:

氧化应激与唐氏综合征 (三体 21) 的发病有关.
调节氧化还原稳定和抗氧化防御的基因位于21号染色体上.

研究的目的:

评估转录因子NRF2和NFKB,以及抗氧化酶CSE和NQO1作为唐氏综合征 (DS) 产前查的潜在生物标志物.
评估这些生物标志物在羊水 (AF) 和母体血清 (MS) 中.

主要方法:

一项前性病例控制研究,涉及接受乳切割的孕妇.
28个DS怀孕与37个非DS怀孕的比较.
使用生物标志物定量ELISA套件分析AF和MS样本.

主要成果:

与非DS组相比,DS组的AF和MS都显著增加了NQO1水平 (p < 0.001).
与非DS组相比,DS组的AF和MS中NRF2水平明显较低 (AF中的p = 0.029,MS中的p = 0.022).

结论:

该研究确定了NQO1和NRF2作为检测唐氏综合征的潜在生物标志物.
需要进一步的研究来验证这些发现的非侵入性产前检测.
经过验证的生物标志物可以减少对侵入性手术的需要和相关风险.

关键词:

氨 ?? 细胞检测 (Amniocentesis) 是一个非常重要的过程.抗氧化酶酶是一种抗氧化酶.唐氏综合征是什么意思唐氏综合征氧化应激标志物氧化应激标志物产前诊断在产前诊断.转录因子转录因子

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