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与瘤相关的巨细胞重塑抑制瘤的免疫微环境,并针对免疫疗法进行向治疗

Yan Yang¹, Sijia Li¹, Kenneth K W To²

¹State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China.

Journal of experimental & clinical cancer research : CR

|May 16, 2025

概括

瘤微环境 (TME) 中的瘤相关巨细胞 (TAM) 驱动癌症免疫逃避和免疫治疗耐药性. 针对TAM及其相互作用提供了一个有希望的策略,以提高癌症免疫治疗的有效性.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
癌症研究癌症研究

背景情况:

免疫检查点抑制剂 (ICI) 在癌症免疫治疗中表现有前途,但耐药性仍然是一个重大挑战.
在瘤微环境 (TME) 内的瘤相关巨细胞 (TAMs) 极大地影响瘤进展和免疫逃避.
TAMs调节M1/M2巨细胞平衡并产生免疫抑制的TME,有助于免疫治疗耐受性.

研究的目的:

系统地审查TAMs的起源,功能性可塑性和两极化.
阐明TAMs和其他TME组件在驱动瘤启动,进展和免疫逃避方面的复杂相互作用.
通过调查TAM-TME通信网络来确定优化癌症免疫治疗的新型分子标.

主要方法:

对TAMs,巨细胞极化和TME相互作用的当前文献进行系统审查.
分析调节巨细胞极化和TAM功能的关键信号通路.
探索TAM与TME内的其他细胞和非细胞组成部分之间的交叉通话.

主要成果:

TAMs在塑造免疫抑制性TME中发挥着关键作用,促进瘤生长和免疫逃避.
了解TAM信号通路及其与TME的相互作用对于克服ICI电阻至关重要.
TAM异质性和可塑性带来了挑战,但也为有针对性的治疗策略提供了机会.

结论:

向TAM及其在TME中的相互作用具有显著的潜力,可以提高癌症免疫治疗的疗效.
需要进一步的研究来解码复杂的TAM-TME相互作用,并将临床前发现转化为临床应用.
解决TAM异质性,可塑性和耐药性机制对于在TAM向治疗中实现最佳临床结果至关重要.

关键词:

免疫检查点抑制剂免疫检查点抑制剂免疫逃逸是一种免疫逃避.免疫治疗是一种免疫疗法.瘤微环境是一个微环境.与瘤相关的巨细胞.

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