对代谢性疾病的基于微针的药物输送系统的进展:结构考虑,设计策略和未来前景
Yao Li1,2, Qiu Chen3, Tingting Wang2,4
1Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, China.
Journal of nanobiotechnology
|May 16, 2025
概括
微针 (MNs) 提供了一种有前途的方法来治疗糖尿病和肥胖等代谢疾病,通过将药物有效地输送到皮下组织. 本综述详细介绍了MN设计,材料及其在提高治疗效率和安全方面的应用.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 代谢疾病治疗方法 代谢疾病治疗方法
背景情况:
- 全球代谢性疾病 (包括糖尿病和肥胖) 的流行率不断上升,需要创新的治疗策略.
- 传统的药物输送方法经常面临生物可用性和系统性副作用的挑战.
- 微针 (MNs) 已经成为一种新的跨皮药物输送平台.
研究的目的:
- 审查当前的概念,设计和微针 (MN) 技术的类型.
- 调查MNS的材料,制造方法和药物输送机制.
- 专注于使用MNs来治疗糖尿病和肥胖症.
主要方法:
- 关于微针技术用于代谢疾病治疗的综合文献综述.
- 分析MN材料,制造技术和药物释放动力学.
- 对糖尿病和肥胖的基于MN的疗法最近的研究进展的综合.
主要成果:
- 微针可以提高药物的生物可用性,并通过将治疗药物直接输送到皮下组织来减少系统性副作用.
- 各种MN设计和材料适用于受控和分级的药物释放.
- 在开发用于糖尿病和抗肥胖应用的MNs方面取得了重大进展.
结论:
- 微针技术为管理代谢疾病提供了可行和有效的策略.
- 需要进一步的研究来应对MN生产,评估和临床翻译方面的挑战.
- 优化MNs有可能提高在代谢性疾病管理中的治疗疗效和患者安全.
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