同步与顺序化学放射疗法:肺癌患者的存活率提高
Jinbiao Xu1, Qiao Ji2, Jianxiong Deng1
1Departerment of Oncology, Gaoxin Branch of the First Affiliated Hospital of Nanchang University, No. 7889 Changdong Avenue, High-tech Zone, Nanchang, 330000, Jiangxi, China.
Biomedical engineering online
|May 16, 2025
概括
同时化学放射治疗 (CCRT) 通过提高肺功能和生存率,改善了非小细胞肺癌 (NSCLC) 患者的治疗结果. 然而,CCRT与顺序化疗放射治疗 (SCRT) 相比,放射性肺炎的发病率也更高.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 肺部病理学 肺部病理学
背景情况:
- 肺癌的治疗通常涉及化疗或放射治疗.
- 顺序化疗 (SCRT) 和并发化疗 (CCRT) 是两种不同的治疗方式.
- 了解SCRT与CCRT的比较疗效和毒性对于优化患者护理至关重要.
研究的目的:
- 为了比较SCRT和CCRT在治疗非小细胞肺癌 (NSCLC) 的临床疗效.
- 为了评估辐射肺炎的发病率和对肺功能的影响 (FEV1,FVC,FEV1/FVC) 在两组治疗中.
- 评估SCRT和CCRT对血清瘤标志物和生存结果 (OSR,PFS,OS) 的影响.
主要方法:
- 在2020年1月至2022年12月期间接受治疗的158名NSCLC患者的回顾性分析.
- 患者被分为一个对照组 (SCRT,n=78) 和一个观察组 (CCRT,n=80).
- 临床疗效,不良反应,肺功能,血清瘤标志物和生存率使用CT扫描,肺功能测试和Kaplan-Meier生存分析进行了比较.
主要成果:
- 与SCRT组相比,CCRT组的缓解率 (90.00%与74.36%) 和对照率 (96.25%与89.74%) 显着更高.
- 在治疗后,CCRT显示肺功能得到改善,血清瘤标志物水平降低 (CA125,SCC Ag,CYFRA21-1).
- 虽然CCRT导致了更好的无进展生存 (PFS) 和整体生存 (OS),但它也导致了更高的辐射肺炎发病率 (25.00% vs 8.97%).
结论:
- 与SCRT相比,并发化疗放射治疗 (CCRT) 对NSCLC患者提供了优越的临床疗效,肺功能改善和生存益处.
- 尽管辐射性肺炎增加,但CCRT的整体毒性概况是可控的,并观察到血液学参数的改善.
- 治疗决策应该是个性化的,考虑CCRT与SCRT对每个患者的潜在好处和风险.
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