在患有慢性疼痛的成年人中,ADHD症状和医用大麻使用
David Saunders1,2, Deepika Slawek3, Chenshu Zhang4
1Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Journal of attention disorders
|May 17, 2025
概括
医学大麻 (MC) 在大多数慢性疼痛的成年人中没有改善ADHD症状. 然而,高THCMC的使用与在那些有轻微的基线症状的人中减少了ADHD症状有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 疼痛管理 疼痛管理
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种影响成人的神经发育障碍.
- 医用大麻 (MC) 越来越多地用于慢性疼痛,但其对伴随性ADHD症状的影响尚不清楚.
- 了解MC使用和ADHD症状变化之间的关系对于患者护理至关重要.
研究的目的:
- 调查医学大麻 (MC) 使用与慢性疼痛成年人12个月多的ADHD症状变化之间的关联.
- 探索MC的使用,不同的THC含量和基线ADHD严重程度是否会影响症状轨迹.
主要方法:
- 一项纵向队列研究,涉及223名患有慢性疼痛的成年人,持续了12个月.
- 混合效应线性回归被用来分析ADHD症状的变化.
- 参与者每季度对MC使用 (包括THC含量) 和ADHD症状进行评估,根据基线ADHD严重程度和疼痛灾难化分层.
主要成果:
- 医用大麻 (MC) 的使用与整体样本或在基线中度至重度ADHD患者中ADHD症状的变化无关.
- 在具有轻度或没有基线ADHD症状的个体中,高THCMC与低THCMC相比,与ADHD症状的减少有关.
结论:
- 目前的研究结果表明,在有中度至重度症状的个体中,MC不太可能是ADHD的有效治疗方法.
- 由于样本大小和研究局限性,轻度ADHD病例的初步积极结果需要谨慎解释.
- 在更大,多样化的群体中进行进一步的研究是有必要的,以澄清MC在管理ADHD症状中的作用,特别是在慢性疼痛患者中.
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