肝移植作为癌症治疗方法:综合性审查
Bobby V M Dasari1,2, Pal-Dag Line3, Gonzalo Sapisochin4
1Department of Liver Transplantation and HBP Surgery, Queen Elizabeth Hospital, Birmingham, UK.
BJS open
|May 17, 2025
概括
对各种癌症的肝移植正在扩大. 本综述通过详细介绍当前的癌症症状,技术方面以及移植候选人的解决方案来优化护理,帮助医疗保健专业人员.
科学领域:
- 肝胆道手术 肝胆道手术
- 移植瘤学 移植瘤学
- 外科胃肠道外科手术
背景情况:
- 对于癌症的征兆,越来越多地使用肝移植.
- 优化对癌症肝移植候选人的护理至关重要.
- 这一综述强调了专业中心目前的战略.
研究的目的:
- 审查癌症患者肝移植的当前指示.
- 讨论癌症肝移植的技术方面,障碍和解决方案.
- 为专门中心的医疗保健专业人员提供有关癌症肝移植策略的指导.
主要方法:
- 对最近的研究进行了全面的文献综述.
- 专注于癌症症状,包括结直肠癌,肝转移,胆管癌,神经内分泌瘤,肝细胞癌和肝上皮状血管内皮瘤.
- 对选择标准和创新方法的证据分析.
主要成果:
- 对结直肠肝转移的证据的讨论 (SECA I,II,TRANSMET研究).
- 对胆管癌的手术前方案和对肝细胞癌和神经内分泌瘤的选择标准的审查.
- 探索器官短缺的创新策略:机器穿透的移植,活体供体肝移植和RAPID手术.
结论:
- 肝移植的癌症征兆已经确立并正在发展.
- 未来的选择标准将包括先进的预测工具,如放射学,基因组学和循环DNA/RNA.
- 需要进行国际注册研究,以克服证据和患者队列的局限性.
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