,miRNA-

Nan Sheng1, Yunzhi Liu1, Ling Gao1

  • 1Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, ChangChun 130012, China.

概括

这项研究介绍了DLST-MDA,这是一种新的深度学习方法,用于预测微RNA与药物相关性 (MDA). 它有效地使用序列和结构数据,优于癌症耐药性研究的现有计算方法.

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RNA Interference

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Nucleic Acid Structure

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DNA Structure
DNA has a double-helix structure. The...