局部胰岛素作为治疗长期表皮缺陷和其他眼睛表面疾病的新疗法:系统性审查
Raluca Bievel Radulescu1,2, Stefano Ferrari3, Horia T Stanca4
1Fondazione Banca Degli Occhi del Veneto, Via Paccagnella, 11, 30174, Venice, Italy. raluca.bievel@fbov.it.
概括
局部眼部胰岛素对各种眼部疾病具有治疗潜力,显著改善角膜愈合率,没有副作用. 这项研究评估了它对眼睛表面病理的有效性和安全性.
科学领域:
- 眼科医生 眼科 眼科
- 再生医学是一种再生医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 眼睛表面病理在治疗中存在重大挑战.
- 对于诸如长期上皮质缺陷和干眼综合征等疾病的传统疗法存在局限性.
- 局部胰岛素为眼睛表面修复提供了一个新的治疗途径.
研究的目的:
- 系统地审查局部眼睛胰岛素对眼睛表面病理的治疗潜力.
- 为了评估不同度,剂量,制备方法和局部胰岛素眼滴的有效性.
- 评估眼科局部胰岛素使用的安全性和不良影响.
主要方法:
- 在主要数据库 (PubMed,Cochrane Library,Scopus,Web of Science) 进行系统的文献搜索.
- 包含13项相关研究,但不包括重复研究,动物研究和病例报告.
- 使用纽卡斯尔-太华尺度和贾达德尺度进行方法质量评估.
主要成果:
- 包括268名患者使用局部胰岛素眼滴 (0.52 U/ml) 通常每天四次.
- 在各种疾病中显示出在角膜愈合率方面显著的眼睛益处.
- 没有报告任何不良影响;研究表明方法质量中等至高.
结论:
- 局部胰岛素是治疗长期表皮缺陷,糖尿病角膜病变,神经营养角膜病变和干眼综合征的有前途的治疗方法.
- 它显著增强角膜愈合,具有有利的安全性.
- 局部胰岛素是一种经济有效的,可访问的替代方案或对现有疗法,如自律血清和羊水膜移植的辅助.
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