在老年患有转移性结肠直肠癌的老年患者中进行向治疗和免疫治疗
Wenjie Huang1,2, Yunpeng Liu3,4
1Department of Medical Oncology, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang City, China.
Current treatment options in oncology
|May 17, 2025
概括
患有转移性结直肠癌 (mCRC) 的老年患者需要量身定制的治疗方法. 本综述强调了针对性治疗和免疫疗法的进展,强调了适合和脆弱的老年人个性化的方法.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 超过一半的转移性结直肠癌 (mCRC) 患者年龄超过65岁.
- 老年人有减少的器官储备和并发症,影响治疗耐受性.
- 目前的指导方针可能无法充分满足老年和脆弱的mCRC患者的需求.
研究的目的:
- 审查针对老年mCRC患者的向治疗和免疫疗法的最新进展 (过去5年).
- 为优化这一群体的治疗提供基于证据的参考资料.
- 讨论基于患者健康状况和瘤特征的治疗方法的适用性.
主要方法:
- 文献审查侧重于VEGF向剂,EGFR抑制剂,多向的TKI和免疫治疗.
- 对适合与脆弱的老年mCRC患者的治疗策略的分析.
- 在治疗规划中考虑综合老年病评估.
主要成果:
- 适合的老年患者可以接受剂量减少的VEGF药物化疗或单剂化疗加VEGF药物.
- 易受伤害的老年患者可以从VEGF药物单剂化疗中获益;EGFR抑制剂是RAS野生型左侧瘤的选择.
- 对于微卫星不稳定性高/不匹配修复缺陷的老年患者,建议使用单剂免疫疗法.
结论:
- 以全面的老年病学评估为指导的个性化治疗策略对于老年mCRC患者至关重要.
- 针对VEGF的向剂和免疫疗法在特定的老年mCRC亚组中表现有前途.
- 需要进一步的研究来完善这种多样化的患者群体的治疗方案.
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