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改变的CD27相关的T细胞子集反映了系统性红斑狼的免疫失衡

Xiaoning Chen¹, Bing Shen², Weijie Lin³

¹Department of Clinical Laboratory, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, China.

Immunologic research

|May 17, 2025

概括

在全身性红斑狼 (SLE) 患者中,CD27+ T 细胞,包括调节性 T 细胞 (Tregs) 的减少表明早期免疫失调. 这些发现凸显了CD27作为SLE诊断的潜在生物标志物.

科学领域:

免疫学免疫学免疫学
T细胞生物学T细胞生物学
自身免疫性疾病是一种自身免疫性疾病.

背景情况:

系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,其特征是免疫失调.
CD4+ T 细胞和调节性 T 细胞 (Tregs) 在维持免疫平衡中起着至关重要的作用.
CD27是一种在淋巴细胞上表达的跨膜蛋白,参与免疫细胞的分化和功能.

研究的目的:

分析CD4+ T细胞子集中的CD27表达.
为了研究CD27+ T细胞子集的功能特征.
在新诊断的SLE患者中评估CD27+T细胞和Tregs的免疫学变化.

主要方法:

来自34名SLE患者和22名健康对照者的外周血液样本.
流细胞计分析T细胞子集上的CD27表达和功能标记物.
在SLE患者和对照者之间对Tregs和CD4+T细胞的CD27表达的比较.
接收器运行特征 (ROC) 曲线分析以确定诊断值.

主要成果:

在SLE患者中增加Tregs的比例.
CD27+CD4+T细胞显示CD45RA的表达率较高,CD226的表达率较低.
CD27+ Tregs表现出较高的Helios和TIGIT,以及较低的CD226表达.
在SLE患者中显著降低了CD27+ CD4+ T细胞和CD27+ Tregs的比例.
与CD27相关的子集的曲线下的面积 (AUC) 从0.6238到0.86.8不等.

结论:

CD27+ CD4+ T细胞显示减少激活标记.
CD27+ Tregs 显示出增强的监管潜力.
在SLE患者中CD27+ T细胞和Treg细胞数量的减少表明早期免疫失调和潜在的诊断效用.

关键词:

CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD4+ T 细胞是 CD4+ T 细胞.监管性T细胞监管性T细胞系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.

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