与代谢功能障碍相关的稳态性肝病的患病率:跨越不同印度人群的映射 (MAP研究)
Viswanathan Mohan1, Shashank Joshi2, Saket Kant3
1Madras Diabetes Research Foundation (ICMR-Collaborating Centre of Excellence) & Dr. Mohan's Diabetes Specialities Centre (IDF Centre of Excellence in Diabetes Care), No 4, Conran Smith Road, Gopalapuram, Chennai, Tamil Nadu, 600086, India. drmohans@diabetes.ind.in.
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响了68.2%的印度人,区域差异很大. 北印度的负担最大,需要针对这一日益严重的问题进行量身定制的公共卫生干预.
科学领域:
- 肝病学和胃肠道学
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个显著且日益严重的全球健康问题.
- MASLD与肥胖,久坐不动行为和代谢综合征密切相关.
- 由于遗传,饮食和社会经济因素,印度经历了多样化的MASLD流行,需要进行区域评估.
研究的目的:
- 为了确定印度不同地理区域的MASLD的流行程度和严重程度.
- 检查MASLD和相关肝脏疾病负担的区域差异.
- 为印度的MASLD管理制定有针对性的公共卫生战略.
主要方法:
- 一项回顾性,多中心的,横截面研究,涉及13,750名来自印度6个地区的105个诊所的成年人 (2023年5月至2024年2月).
- 使用控制衰减参数 (CAP) 和肝硬度测量 (LSM) 通过FibroScanTM进行肝硬化和纤维化的非侵入性评估.
- 根据已建立的CAP和LSM值,对MASLD严重程度 (轻度,中度,严重) 和纤维化阶段 (F0-F4) 的分类.
主要成果:
- 整体MASLD患病率为68.2% (CAP≥238dB/m),纤维化患病率为33.7% (LSM≥7kPa).
- 北印度的MASLD负担最高 (73.3%),而Uttarakhand显示 80.0%.
- 在MASLD患病率 (P < 0.001) 中观察到显著的区域差异,但与年龄没有关联;严重纤维化在喀拉拉 (20.0%),严重脂肪酸在查和克什米尔 (50.3%) 高.
结论:
- 这项研究揭示了印度各地MASLD患病率和严重程度的区域差异.
- 北印度的高MASLD负担强调了对特定区域的公共卫生干预措施的需要.
- 标准化查和预防策略对于解决全国范围内的各种MASLD负担至关重要.
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