协同效应和kolaviron和quercetin对大鼠模型良性前列腺增生症的生物化学评估
Ujong P Ujong1,2, Mbang E Ibor2, Iwara A Iwara2
1Department of Medical Biochemistry, Faculty of Basic Medical Sciences, University of Cross River State, Okuku Campus, Cross River State, 540001, Nigeria.
Journal of Asian natural products research
|May 17, 2025
概括
科拉维龙和奎尔素通过减少关键标志物和改善健康指标,有效地管理良性前列腺增生症 (BPH). 这些天然化合物显示出作为BPH的可访问,非侵入性治疗方法的希望.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 良性前列腺增生症 (BPH) 是老年男性常见的疾病.
- 目前用于BPH的治疗方法有局限性和副作用.
研究的目的:
- 为了研究kolaviron和quercetin对大鼠丸激素诱导的BPH的影响.
- 评估这些化合物作为BPH的治疗剂的潜力.
主要方法:
- 在雄性Wistar大鼠中诱导了良性前列腺增生 (BPH).
- 鼠被用科拉维龙,奎尔塞丁,它们的组合或费纳斯特治疗.
- 分析了生物化学标记物 (PSA,5-α减少酶,DHT,脂质特征,肝/功能) 和组织病理学.
主要成果:
- BPH诱导增加了前列腺大小,PSA,5-α减少酶,DHT,以及改变的脂质样本和肝/功能标志物.
- 科拉维龙和奎尔丁治疗,单独或联合,显著减少了这些BPH诱导的变化.
- 治疗也改善了丸激素和HDL-c水平.
结论:
- 科拉维龙和奎尔丁在改善与BPH相关的生化和病理学变化方面表现出显著的有效性.
- 这些天然化合物代表了管理BPH的潜在负担得起和非侵入性治疗选择.
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