缺血修饰的白蛋白和氧化应激标记在急性尾炎:一个前性研究
Ozan Caliskan1, Beyza Nur Ozkan2, Mehmet Taner Unlu1
1Department of General Surgery, University of Health Sciences Turkey, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
The Journal of surgical research
|May 17, 2025
概括
缺血变异性白素 (IMA) 在区分穿孔性尾炎和急性尾炎方面表现有前途. 增加的氧化应激和炎症标志物也有助于诊断,改善患者的治疗结果.
科学领域:
- 生物化学 生物化学
- 临床诊断 临床诊断 临床诊断
- 手术紧急情况 手术紧急情况
背景情况:
- 急性尾炎是经常出现的手术紧急情况.
- 穿孔性尾炎带来更高的并发症风险,需要早期诊断.
研究的目的:
- 评估生化,血液学和炎症标志物的诊断价值.
- 为了区分急性尾炎和穿孔尾炎.
主要方法:
- 87名参与者的前性研究 (29例急性尾炎,29例穿孔尾炎,29例对照).
- 测量了血清尿素,肌,乳酸脱酶,C反应蛋白,全血参数,氧化应激标志物 (总氧化剂状态,氧化应激指数,二硫化物,IMA) 和炎症标志物 (IL-1β,IL-6,TNF-α).
主要成果:
- 尾炎组显示尿素,乳酸脱酶,C反应蛋白,白细胞和血小板数量增加.
- 在尾炎中观察到氧化应激标记的增加和抗氧化剂标记的减少.
- 炎症标志物 (IL-1β,IL-6,TNF-α) 显著升高,特别是在穿孔尾炎中.
结论:
- 缺血变异性白蛋白 (IMA) 是区分穿孔尾炎的潜在生物标志物.
- 对氧化应激和炎症标记物的联合分析可以提高诊断准确度.
- 基于准确诊断的及时干预可以减少并发症.
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