使用带有非平面光学波导的微创针来测量乳酸盐度
Daigo Koiwa1, Yoichi Haga1, Noriko Tsuruoka1
1Graduate School of Engineering, Tohoku University, 6-6 Aza-Aoba, Aramaki, Aoba-ku, Sendai, Miagi, Japan.
Biosensors & bioelectronics
|May 17, 2025
概括
这项研究在针针上引入了一种最小侵入性的光学装置,用于在组织中持续监测乳酸. 该设备通过光吸收来测量乳酸盐度,有望用于日常健康跟踪.
科学领域:
- 生物医学工程 生物医学工程
- 光学传感传感器是什么?
- 生物技术是生物技术.
背景情况:
- 传统的生物物质血液采样方法具有侵入性,不适合持续监测.
- 对乳酸等生物标志物的持续监测对于有效的健康管理和疾病检测至关重要.
研究的目的:
- 开发和评估一种最小侵入性的光学装置,用于在皮下组织中持续测量乳酸度.
- 评估在针针上使用光学波导在生物传感应用中的可行性.
主要方法:
- 设计了一种使用光学波导集成到针针 (200微米直径) 上的装置.
- 该设备使用与组织中的乳酸盐度相关的吸收度测量.
- 应用了生物相容的环氧涂层,以提高针的穿透性并降低插入阻力.
主要成果:
- 该设备成功测量了溶液中的乳酸盐度,并观察到光强度随着乳酸盐水平的增加而下降.
- 针针表现出良好的穿透性,有助于生物相容涂层.
- 实验数据证实了吸收率和乳酸盐度之间的相关性.
结论:
- 开发的最小侵入性光学装置显示了在皮下组织中持续监测乳酸的潜力.
- 需要进一步优化以减少光学损失并提高实际应用的测量精度.
- 未来的研究将专注于微型化和多分析器传感,用于日常健康监测.
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