乙化纤维素通过消耗宿主可获得的碳水化合物消耗的肠道共生体抑制体质增加
Tadashi Takeuchi1, Eiji Miyauchi2, Yumiko Nakanishi1
1Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Cell metabolism
|May 17, 2025
概括
乙化纤维素 (AceCel) 通过改变肠道细菌,有效地减少小鼠的体重增加. 这种益生菌促进脂肪酸氧化,限制碳水化合物代谢,提供了一种新的肥胖治疗策略.
科学领域:
- 微生物学 微生物学
- 代谢过程中的代谢.
- 肥胖问题研究研究
背景情况:
- 肥胖需要新的预防和治疗策略,而不仅仅是直接调节宿主代谢.
- 肠道微生物群是调节营养可用性和宿主生理学的有希望的目标.
研究的目的:
- 研究乙化纤维素 (AceCel) 对体重增加和宿主新陈代谢的影响.
- 探索肠道微生物群在调解AceCel的作用中的作用.
主要方法:
- 给野生型和肥胖小鼠使用AceCel.
- 分析肠道细菌的组成和功能.
- 对宿主肝脏碳水化合物和脂肪酸氧化的评估.
主要成果:
- 在两种小鼠模型中,AceCel显著降低了体重增加.
- AceCel改变了肠道微生物群的组成和功能.
- 通过AceCel介导的作用包括减少碳水化合物氧化和增加肝脏中的脂肪酸氧化.
- 由肠道细菌产生的酸盐增强了碳水化合物发酵,减少了可用的糖.
结论:
- AceCel充当益生菌,调节细菌和宿主碳水化合物代谢.
- 通过通过肠道微生物群调节能量代谢,AceCel显示出作为治疗肥胖的治疗策略的潜力.
相关概念视频
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
134
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
134
Metabolic States of the Body: The Absorptive State
633
During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
633
Carbohydrate Metabolism
10.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.7K
Carbohydrate Absorption
387
Carbohydrates are essential macronutrients that serve as the body's primary energy source. Their digestion begins in the mouth, where salivary amylase partially breaks down complex carbohydrates such as starch into smaller oligosaccharides. This mechanical and enzymatic activity prepares carbohydrates for further processing in the gastrointestinal tract.
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...
387
Cellulose and Pectic Polysaccharides
3.4K
Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
As a cell matures, its cell wall specializes according to its type. For example, the...
3.4K
Role of Microtubules in Cell Wall Deposition
2.3K
Microtubules are small hollow tubes in eukaryotic cells. The cell wall microtubules are polymerized dimers of two globular proteins, α-tubulin and β-tubulin, two globular proteins. With a diameter of about 25 nm, microtubules are the widest components of the cytoskeleton. They help the cell resist compression and provide a track along which vesicles move through the cell or pull replicated chromosomes to opposite ends of a dividing cell. Microtubules go through quick cycles of...
2.3K


