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空气污染暴露对月经周期健康的影响,使用来自移动健康应用程序的自我报告数据:一项前性观察性研究

Priyanka N deSouza¹, Amanda A Shea², Virginia J Vitzthum³

¹Department of Urban and Regional Planning, University of Colorado Denver, Denver, CO, USA; CU Population Center, University of Colorado Boulder, Boulder, CO, USA; Senseable City Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.

The Lancet. Planetary health

|May 17, 2025

概括

长期暴露于细颗粒物 (PM2.5) 与女性月经周期不规律有关. 这项研究强调了空气污染.

科学领域:

环境健康环境健康
生殖健康生殖健康
毒理学毒理学毒理学

背景情况:

环境空气污染,特别是细颗粒物 (PM2.5),被怀疑具有内分泌干扰性质.
月经周期的运行是女性生殖健康的关键指标.
以前的毒理学数据表明,空气污染与对月经周期的不良影响之间存在联系.

研究的目的:

调查短期和长期暴露于PM2.5和月经周期结果之间的关联.
分析来自美国,巴西和墨西哥移动健康应用程序的数据.

主要方法:

使用Clue移动健康应用程序 (2016-2020) 的非识别数据进行前性观察研究.
包括230个城市的92,550名年龄在18-44岁之间的不使用荷尔蒙避孕药的用户.
分析了城市层面和周期层面的结果,包括异常周期长度 (<24或>38天),使用回归分析,控制混因素.

主要成果:

在长期暴露于PM2.5和高比例异常长或短的月经周期 (OR 1.023) 之间发现了显著的关联.
长期的PM2.5暴露也与每10μg/m3增加的异常长周期 (OR1.036) 的比例更高有关.
在短期的PM2.5暴露和异常周期长度之间没有观察到显著的关联.

结论:

暴露于PM2.5似乎会影响月经周期的规律性.
需要进一步的研究,以了解PM2.5对月经周期的影响背后的特定生物机制.

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