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Updated: May 23, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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针对KRAS和SOS1作为抗瘤剂的PROTACs的概述

Zhiqiu Han1, Qianping Wu1, Hongxin Rao1

  • 1School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.

Bioorganic & medicinal chemistry letters
|May 17, 2025
PubMed
概括

用PROTAC准KRAS和SOS1为治疗KRAS驱动的癌症提供了一个新的策略. 这种方法旨在克服对现有疗法的耐药性,并解决像G12D和G12V这样的突变.

关键词:
抗瘤剂是一种抗瘤剂.克拉斯 (Kras) 是一个国家.这就是PROTAC.这就是SOS1的意义.

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