解码慢性压力:从小鼠的行为分子动态到皮质醇和IL-17在抑郁症严重性的临床影响
Yanlin Tao1, Zikang Li2, Jinfeng Yuan2
1Shanghai Key Laboratory of Compound Chinese Medicines, the Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, the MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; Institute for Translational Brain Research, Fudan University, Shanghai, PR China.
Journal of affective disorders
|May 17, 2025
概括
慢性压力加快抑郁,皮质醇和IL-17被确定为关键生物标志物. 这些在小鼠模型和人类参与者的发现为抑郁症进展和潜在的有针对性的干预提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 分子生物学分子生物学
背景情况:
- 慢性压力是抑郁症发病和严重程度的一个重要因素.
- 了解将压力与抑郁症联系起来的分子机制,对于开发有效的治疗方法至关重要.
- 使用动物模型和人体研究的翻译方法可以提供全面的见解.
研究的目的:
- 为了研究慢性压力,分子变化和抑郁症严重程度之间的关系.
- 通过转化方法确定抑郁症严重程度的潜在生物标志物.
- 根据已识别的生物标志物,开发预测模型来区分抑郁症严重程度.
主要方法:
- 将小鼠暴露在不同频率的慢性压力因素中,然后进行行为和血清指标分析.
- 招募了239名人类参与者 (137名抑郁症患者,102名对照患者) 进行血资料分析.
- 对血皮质醇和炎症性细胞因子 (IL-17) 的测量,以及机器学习模型的开发.
主要成果:
- 在老鼠中观察到慢性压力强度和行为分子变化之间的剂量反应关系.
- 皮质醇和IL-17被确定为区分抑郁症严重程度的潜在生物标志物.
- 机器学习模型在区分抑郁症严重程度方面表现出强大的能力.
结论:
- 皮质醇,IL-17和慢性压力强度之间存在相关性,这表明压力加速抑郁.
- 皮质醇和IL-17显示出对理解抑郁症进展的诊断潜力.
- 这项研究增强了对抑郁症中压力诱导的分子变化的理解,为有针对性的干预提供了信息.
更多相关视频
相关概念视频
Psychoneuroimmunology: Diabetes and Cancer
20
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
20
Stress and Mental Health
65
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
65
Psychoneuroimmunology: Cardiovascular Disease
22
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
22
Introduction to Stress and Lifestyle
56
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
56


