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Updated: May 20, 2025

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氨基酸-tRNA-蛋白L/F和R转移酶的结构和机制

Misti Cartwright1, Rajat Kumar Jha1, Aaron T Smith1

  • 1Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250 USA.

Journal of molecular biology
|May 17, 2025
PubMed
概括

氨基酸-tRNA-蛋白转移酶 (aa-转移酶) 是一种酶,在蛋白质降解中起着关键作用. 最近的结构研究揭示了它们的机制,特别是真核细胞R转移酶 (ATE1s),指导着未来的治疗开发.

关键词:
在ATE1中,ATE1是ATE1.氨基酸-tRNA-蛋白转移酶.在Clp路径上.在L/F-转移酶.在N-degron路径上.在R-转移酶.阿尔吉尼化 (Arginylation) 是一种后翻译修改后的修改

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