慢性胰腺炎和胰腺外癌 - - 一项系统性审查和元分析
Shauntelle Quammie1, Colin John Crooks1, Abdulsalam Aliyu2
1NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, UK; Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
概括
患有慢性胰腺炎 (CP) 的患者面临患胰腺外 (EP) 癌症,特别是肺癌和肝癌的风险更高. 改变生活方式,如戒烟和减少饮酒,可以减轻这种增加的癌症风险.
科学领域:
- 胃肠道学和瘤学
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 慢性胰腺炎 (CP) 是胰腺癌的已知危险因素.
- 胰腺癌和胰腺外癌 (EP) 之间的关联尚不清楚.
- 本系统性审查调查了CP作为EP癌症的风险因素.
研究的目的:
- 系统地审查和综合有关慢性胰腺炎和胰腺外癌之间的联系的证据.
- 量化CP患者中EP癌症的流行率,发病率和相对风险.
主要方法:
- 对奥维德·梅德林,EMBASE和Scopus数据库进行系统的文献搜索.
- 包括16项研究,包括117,163名CP患者.
- 随机效应的元分析,以聚合EP癌症的流行率,发病率和危险比率 (HR).
主要成果:
- 在CP患者中,3.4%患有EP癌症.
- 肺癌在CP患者中显示了EP癌症中最高的年度流行率和发病率.
- 患者患有肺癌 (HR 1.31) 和肝癌 (HR 1.58) 的风险显著增加.
结论:
- 患有CP的患者患EP癌症的风险较高,特别是肺癌和肝癌.
- 可修改的风险因素,如吸烟和饮酒,都与此有关.
- 非侵入性查可能有助于在高风险人群中早期诊断.
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