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Updated: May 21, 2025

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Published on: August 9, 2022

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固态口服药物的长期稳定性暴露于模拟的车内静脉空间辐射

Ianik Plante1, Vernie Daniels2, Millennia Young3

  • 1KBR, Houston, TX, USA. Ianik.Plante-1@nasa.gov.

NPJ microgravity
|May 17, 2025
PubMed
概括

在模拟太空辐射暴露后,太空任务药物乙氨基,阿莫西西林,布洛和普罗米他的稳定性进行了测试. 结果显示,银河系宇宙辐射 (GCR) 不会加速药物降解,确保宇航员的药物安全.

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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