持续的母乳养与从童年后期到青春期早期的大脑结构和认知相关
Jonatan Ottino González1, Miguel Angel Rivas Fernández1, Sevan Esaian1
1Division of Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Pediatric research
|May 17, 2025
概括
长期母乳养对青少年的神经认知有积极的影响,增强大脑结构和流体认知. 更长的母乳养时间与更大的皮质厚度,表面积和髓有关,支持长期的认知健康.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿科 儿科 儿科
背景情况:
- 哺乳有益于早期的神经认知,但其对青春期的长期影响尚不清楚.
- 青春期是大脑发育和心理健康的关键时期.
- 了解母乳养对青少年神经发育的影响至关重要.
研究的目的:
- 为了研究母乳养时间与青少年神经认知发展之间的纵向关联.
- 为了检查母乳养对大脑结构 (皮层厚度,表面积,髓) 和流体认知的影响.
- 确定皮质特征是否调解了母乳养和流体认知之间的关系.
主要方法:
- 使用青少年大脑认知发展 (ABCD) 研究® (n=5098在基线,n=3810在随访) 的数据进行长度研究.
- 估计的母乳养时间 (从未,1-6,7-12,>12个月).
- 使用MRI测量皮层厚度,表面积和髓;评估流体认知. 使用线性混合效应模型和调解分析分析数据.
主要成果:
- 较长的母乳养时间与皮质厚度,表面积和流体认知增加有关.
- 对皮质髓观察到积极的关联,一些区域显示出更多的髓,而另一些区域显示出随着时间的推移而增加.
- 青少年大脑表面积调解了母乳养时间和流体认知之间的关系.
结论:
- 哺乳时间对青少年神经认知有剂量依赖的积极影响.
- 长期母乳养与增强的大脑结构和认知功能有关,具有持久的影响.
- 研究结果支持扩大母乳养实践,以实现最佳的神经发育和潜在的长期健康益处.
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