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贝宁20年抗虫剂耐药性:对进化和驱动因素的回顾性分析
Steve Zinsou Hougbe1,2,3, Razaki A Ossé4,5,6, Roseric Azondékon4
1Laboratoire de Biologie et de Typage Moléculaire en Microbiologie (LBTMM), Département de Biochimie et de Biologie Cellulaire (BBC), Université de Abomey-Calavi (UAC), Abomey-Calavi, Benin. hougbesteve@gmail.com.
Malaria journal
|May 17, 2025
概括
在贝宁的抗虫剂耐药性.
科学领域:
- 昆虫学 昆虫学是一门学科.
- 分子生物学分子生物学
- 公共卫生 公共卫生
背景情况:
- 蚊子载体对杀虫剂的耐药性在贝宁越来越令人担忧.
- 之前的研究显示,两十年来对抗性趋势的数据是零碎的.
研究的目的:
- 追溯分析贝宁现有的关于抗虫剂耐药性的数据.
- 为了评估20年来蚊子载体对杀虫剂耐药性的演变.
主要方法:
- 从1996-1998年和2010-2024年收集的数据.
- 提取的研究年份,WHO协议的遵守,蚊子物种,地点特征,杀虫剂和耐药机制.
- 排除了超过5年的数据差距的市镇.
主要成果:
- 1999年首次发现的甲状腺耐药性,现在在贝宁各地广泛和严重.
- 在Anopheles gambiae s.l.中,kdr L1014F突变频率从10%上升到90%. 在阿拉达从2011年到2024年.
- 排毒酶活性和抗 bendiocarb 和 pirimiphos 甲基的耐药性显示越来越多的趋势.
结论:
- 贝宁的抗虫剂耐药性,最初是用有机和后来用铁,在过去的20年里显著加剧.
- 耐药性现在影响所有生态区,需要更新载体控制策略.
- 在未来的贝宁疟疾控制运动中,优先考虑新的杀虫剂处理网.
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