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在美国人口中,口腔微生物群多样性与慢性阻塞性肺病之间的关联

Xian-Xin Xia¹, Chuan-Xiang Li¹, Hong-Rong Guo²

¹Department of Respiratory and Critical Care Medicine, The Third Hospital of Wuhan, Wuhan, 430030, People's Republic of China.

Journal of translational medicine

|May 17, 2025

概括

较低的口腔微生物群多样性与慢性阻塞性肺病 (COPD) 风险增加有关. 这项研究发现,COPD患者和没有COPD患者之间的口腔微生物群落存在显著差异.

科学领域:

微生物组研究的研究.
肺部医学肺部医学
基因组学就是基因组学.

背景情况:

关于口腔微生物群多样性和COPD风险的基于人口的研究很少.
了解这种关系对于识别COPD潜在生物标志物和治疗点至关重要.

研究的目的:

调查口腔微生物群多样性 (α和β多样性) 与慢性阻塞性肺病 (COPD) 风险之间的关联.

主要方法:

来自国家健康和营养检查调查 (NHANES 2009-2012) 的截面数据的分析.
利用多变量后勤回归和限制立方线来评估α多样性和COPD风险.
采用主要坐标分析 (PCoA) 和变多变量变异分析 (PERMANOVA) 来分析COPD和非COPD组之间的β多样性差异.

主要成果:

总共有6061名参与者被纳入.
阿尔法多样性指标 (观察到的ASV,Faith的家族遗传多样性,Shannon-Weiner指数) 与COPD风险有显著的负相关性.
贝塔多样性分析显示,COPD和非COPD组之间的微生物社区结构 (Bray-Curtis,未加权和加权的UniFrac距离) 在统计学上有显著差异 (P <0.01).

结论:

在患有和没有COPD的个体之间,口腔微生物群的α和β多样性存在显著差异.
减少口腔微生物群多样性与COPD风险有负面关联,这表明它可能在疾病发展中起作用.

关键词:

慢性慢性肺炎是一种慢性慢性肺炎,COPD是一种慢性肺炎.多样性多样性多样性多样性尼汉斯 (NHANES) 是一个名人.口腔微生物组是口腔的微生物组.

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