在患有癌症的老年人中管理类风湿性关节炎
Maria A Lopez-Olivo1, Aliza R Karpes Matusevich2, Jean H Tayar3
1Department of Health Services Research, Unit 1303, The University of Texas MD Anderson Cancer Center, 1155 Pressler St, Houston, TX, 77030, USA. amlopezo@mdanderson.org.
Drugs & aging
|May 18, 2025
概括
患有类风湿性关节炎 (RA) 的老年人面临更高的癌症风险和由于炎症和衰老的生存率较低. 除了癌症外,还需要个性化护理来管理RA,以平衡症状控制和治疗安全.
科学领域:
- 类风湿病学 类风湿病学
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
背景情况:
- 风湿性关节炎 (RA) 不成比例地影响老年人,增加他们患癌症等并发症的风险.
- 慢性炎症,免疫和共同的风险因素 (如吸烟) 导致RA患者的癌症风险增加.
- 关节炎患者的癌症存活率通常较低,特别是肺癌和淋巴瘤.
研究的目的:
- 审查类风湿性关节炎 (RA) 患者恶性瘤的患病率.
- 检查风险因素,治疗挑战和老年人RA癌症的癌症管理策略.
- 总结临床指导方针,以优化在这一群体的护理.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 对患病率,风险因素和治疗挑战的分析.
- 临床指导方针和共识陈述的总结.
主要成果:
- 由于慢性炎症,衰老和共同的风险因素,RA患者的老年人患癌症的风险增加.
- RA 患者的癌症存活率下降,尤其是肺癌和淋巴瘤.
- 关节炎治疗可能会略微增加癌症风险,但对疾病管理至关重要;癌症诊断后需要进行调整.
结论:
- 在有癌症史的老年人中治疗RA需要个性化,多学科的方法.
- 平衡RA症状控制与癌症治疗结果至关重要.
- 共享决策和非药物干预措施提高了患者的生活质量和护理.
- 需要进一步的研究来完善这种复杂的患者群体的基于证据的指导方针.
相关概念视频
Psychoneuroimmunology: Diabetes and Cancer
20
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
20
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Asthma-IV: Nursing Management
2.9K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
2.9K
Treatment Resistant Cancers
3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
Chronic Obstructive Pulmonary Disease-V: Management
2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
2.5K
COPD: Management Using Bronchodilators and Corticosteroids
159
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
159


