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在炎症性肠道疾病中,代谢途径的明显扰乱与疾病进展有关
Arno R Bourgonje1, Susanne Ibing2,3,4, Alexandra E Livanos1
1The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
Journal of Crohn's & colitis
|May 18, 2025
概括
特定的血液代谢物和代谢途径与炎症性肠病 (IBD) 的疾病进展有关. 这些发现可能有助于确定克罗恩病和性结肠炎的新预后生物标志物.
科学领域:
- 代谢学 代谢学 代谢学
- 胃肠病学 胃肠病学
- 生物标志物发现发现
背景情况:
- 炎症性肠病 (IBD) 患者表现出与疾病活性和表型相关的循环代谢物水平变化.
- 这些代谢物和IBD疾病进展之间的关联以前没有被探索.
研究的目的:
- 研究循环代谢物和代谢途径与IBD患者疾病进展风险之间的关系.
- 为了确定IBD进展的潜在预后生物标志物.
主要方法:
- 一个观察性队列研究,利用西奈山克罗恩和结肠炎注册表与纵向电子健康记录数据.
- 基线血清样本的非向代谢分析.
- 采用多变量Cox比例危险回归,L1调节的CoxPH和随机生存森林模型来评估代谢物与疾病进展事件的关联 (新的类固醇/生物处方,住院,手术).
主要成果:
- 在克罗恩病 (CD) 中,有151种代谢物与进展相关,其中81种与风险增加有关 (例如,氨基酸, purin/pyrimidine代谢,胆酸),70种与风险降低有关 (例如,脂肪酸氧化,类固醇生物合成).
- 在性结肠炎 (UC) 中,84种代谢物与进展相关,其中29种与风险增加有关 (例如,脂,硫化,氨酸代谢) 和55种与风险降低有关 (例如,类固醇生物合成,histidine代谢).
- 结合新陈代谢数据和临床参数的生存模型,与仅使用临床变量模型相比,显示出更好的预测性能.
结论:
- 不同的循环代谢物和代谢途径与CD和UC的疾病进展有显著的关联.
- 这些已识别的代谢物和途径代表了预测IBD进展的潜在预后生物标志物.
- 这些发现强调了新陈代谢分析对理解和管理IBD进展的重要性.
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